

See Adding ArcGIS Desktop installation components for more information. You can add or remove components after installing the software. Refer to The ArcGIS Administrator for details.
ARCGIS 10.6 NEW INSTALL
If you need to install to a different location, manually remove your existing installation before starting the 10.6.1 installation. For example, if ArcGIS 10.2 for Desktop was installed to D:\MyGIS\ArcGIS\Desktop10.2, the 10.6.1 installation folder will be D:\MyGIS\ArcGIS\Desktop10.6. This online ArcGIS training course is a perfect introduction to ArcGIS 10.6 and all of its constituent components: ArcMap, ArcCatalog and ArcToolbox.
ARCGIS 10.6 NEW UPGRADE
The parent location of an upgrade installation is retained and the software is installed to \Desktop. For new GIS and/or ArcGIS users who wish to utilise the key functions of the software. An upgrade will not allow you to select or change the installation location. I am using ArcMap 10.6.1 and am trying to install and use pythonwin but i am not having much luck. Don't forget to watch Part 2 This video includes: 00:40 Item Ma. The installation location will be identified in this dialog box or in the custom dialog box, if a custom option was selected. This video showcases some of the features of the latest release of ArcGIS Enterprise 10.6.1.

The Custom installation option allows you to choose specific installation components.

ARCGIS 10.6 NEW UPDATE
Setup.msi will not install if Microsoft Visual C++ 2017 Redistributable (x86) Update 5 is not already installed. If the Visual C++ 2017 Redistributable is not already installed, running setup.exe will install it before setup.msi is launched. ArcGIS Desktop requires Microsoft Visual C++ 2017 Redistributable (x86) Update 5.
